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Major Depressive Disorder Ups Acute MI Risk in HIV-Infected


HealthDay News
Updated: Aug 26th 2016

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FRIDAY, Aug. 26, 2016 (HealthDay News) -- For HIV-infected adults, major depressive disorder (MDD) is associated with an increased risk of acute myocardial infarction (AMI), according to a study published online Aug. 24 in JAMA Cardiology.

Tasneem Khambaty, Ph.D., from the University of Miami in Coral Gables, and colleagues examined whether depressive disorders are associated with incident AMI in a cohort of 26,144 HIV-infected veterans with cardiovascular disease (CVD). At baseline, 19 percent of veterans had MDD and 9 percent had dysthymic disorder.

The researchers found that there were 490 AMI events (1.9 percent) during 5.8 years of follow-up. After adjustment for demographics, CVD risk factors, and HIV-specific factors, baseline MDD correlated with incident AMI (hazard ratios, 1.31 [95 percent confidence interval (CI), 1.05 to 1.62], 1.29 [95 percent CI, 1.04 to 1.60], and 1.30 [95 percent CI, 1.05 to 1.62], respectively). The associations were attenuated after further adjustment for hepatitis C, renal disease, substance abuse, and hemoglobin level (hazard ratio, 1.25; 95 percent CI, 1.00 to 1.56) and antidepressant use (hazard ratio, 1.12; 95 percent CI, 0.87 to 1.42). There was no correlation for baseline dysthymic disorder with incident AMI.

"Our findings raise the possibility that MDD may be independently associated with incident atherosclerotic CVD in the HIV-infected population," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

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